Meta-analysis of patient-reported outcomes and application of minimal important differences to facilitate interpretation in systematic reviews and guideline development


Workshop session 5: Thursday, 14:00-15:30

Workshop category: 

  • Methods for conducting syntheses (including different evidence, searching and information retrieval, statistics, assessing methodological quality)


Date and Location


Thursday 14 September 2017 - 14:00 to 15:30


Contact persons and facilitators

Contact person:


Tahira Devji
Alonso Carrasco-Labra


Guyatt G1, Patrick D2, Johnston B3, Nesrallah G4
1 McMaster, Canada
2 University of Washington, United States of America
3 The Hospital for Sick Children, Canada
4 Humber River Regional Hospital, Canada
Target audience

Target audience: 

Review authors, guideline developers

Level of difficulty: 

Type of workshop

Type of workshop : 



1) Present and apply principles influencing choice of patient-reported outcome measures (PROMs) in systematic reviews.
2) Review the use of minimally important differences (MIDs) in enhancing interpretability of PROMs in systematic reviews.
3) Introduce an instrument for evaluating the credibility of MIDs and apply it to a sample of studies.
4) Help participants apply presentation approaches relying on the MID to make PROMs more interpretable in systematic reviews.

This workshop will build on a workshop presented earlier at the Summit describing approaches to make PROMs more interpretable in systematic reviews, including those relying on MIDs. This workshop will review the principles governing choice of an outcome measure in systematic reviews. Participants will apply the approach to a data set. Then we will review the concept of the MID and its application to enhance interpretability of reviews. We will then introduce an instrument for evaluating the credibility of MIDs in PROMs and participants will apply the instrument to a data set. Finally, participants will apply the methods for using the MID to enhance interpretability to a data set to generate results in MID units, relative effects, and risk differences.