How to conduct reviews of risks of health effects resulting from exposure


Workshop session 6: Thursday, 16:00-17:30

Workshop category: 

  • Methods for conducting syntheses (including different evidence, searching and information retrieval, statistics, assessing methodological quality)


Date and Location


Thursday 14 September 2017 - 16:00 to 17:30


Contact persons and facilitators

Contact person:


Jos Verbeek
Jan Hoving
Target audience

Target audience: 

Intervention review authors that would like to conduct risk factor reviews

Level of difficulty: 

Type of workshop

Type of workshop : 



Objectives: to learn to conduct a systematic review of health effects of environmental or occupational exposure

Description: Methods for conducting intervention reviews are well-established and laid down in the Cochrane Handbook. Reviews of exposure differ from intervention reviews in two fundamental ways. With long-term irreversible outcomes, exposure reviews will be based on observational studies usually cohort and case-control studies instead of RCTs. Where an intervention is an on or off phenomenon, exposure consists of multiple levels. The objective of the exposure review is to establish a dose-response relation.
In the workshop, participants will learn how to:
- formulate a proper PECCOS question as the analogue of PICO;
- how to extract and transform data from studies needed for a dose-response analysis for an air-quality study or a shift work study;
- how to assess risk of bias in a cohort study and a case-control study.
After the workshop, participants with previous knowledge of intervention reviews will be able to assess the quality of exposure reviews.